| abstract |
NEW MATERIAL:A compound expressed by formula I [A is 1W8C alkylene, alkenylene, etc. ; R is H, phenyl, benzyl, etc.; B is 1W8C alkylene which may be substituted by phenyl or benzyl group or single bond; D is halogen, 1W4C alkyl or alkoxy]. n EXAMPLE: N-[3-[N-(2-Phenylethyl)carbamoyl]propanoyl]-L-prolinal. n USE: An antiamnesia having prolylendopeptitase inhibiting activity, preventing metabolism of a substance supposed to participate in neurotransmitter or memory in brain of animals containing human, especially human and useful in prevention and/or remedy for amnesia. n PREPARATION: A novel prolynol derivative expressed by formula II is subjected to oxidation reaction with an oxidant (e.g., sulfur trioxide-pyridine complex) in an inert organic solvent such as DMSO or methylene chloride in the presence or absence of triethylamine, etc., to provide the compound expressed by formula I. n COPYRIGHT: (C)1989,JPO&Japio |