| abstract |
Heterocyclic compounds as PAD inhibitors Heterocyclic compounds of formulas (I), (II), (III) and their polymorphs, steric isomers, prodrugs, solvate compounds, co-crystals, intermediates, Pharmaceutically acceptable salts and their metabolites are described herein. The compounds described herein, their polymorphs, steric isomers, prodrugs, solvate compounds, co-crystals, intermediates, pharmaceutically acceptable salts, and their metabolites are PAD inhibitors. It can be used to treat a variety of diseases such as rheumatoid arthritis, vasculitis, systemic lupus erythematosus, cutaneous lupus erythematosus, ulcerative colitis, cancer, fibrosis, asthma, multiple sclerosis, and psoriasis. [Chemical 1] |