| abstract |
Compounds of formula (I) wherein R 1 is hydrogen or C 1-6 alkyl and R 2 is hydrogen, C 1-6 alkyl, perhalomethyl C 0-5 alkyl-O— or C 1-6 Is alkoxy, R 3 is hydrogen, C 1-6 alkyl or C 1-6 alkoxy C 1-6 alkyl, and R 4 is hydrogen, C 1-6 alkyl, perhalomethyl C 1-6 alkyl, or non- Substituted C 3-6 cycloalkyl C 1-6 alkyl, A is CR 5 or N, B is CR 6 or N, D is CR 7 or N, provided A, At least one of B and D is N, R 5 is hydrogen or C 1-6 alkyl, R 6 is hydrogen or C 1-6 alkyl, R 7 is hydrogen, C 1-6 Alkyl, C 1-6 alkoxy or hydroxy, R 8 is hydrogen or C 1-6 alkyl, provided that one of R 4 and R 8 is hydrogen and R 9 is hydrogen or hydroxy , R 10 is hydrogen or C 1-6 alkyl And their salts are PAD4 inhibitors, and various disorders such as rheumatoid arthritis, vasculitis, systemic lupus erythematosus, ulcerative colitis, cancer, cystic fibrosis, asthma, cutaneous lupus erythematosus and Can be useful in the treatment of psoriasis. [Chemical 1] [Selection figure] None |