| abstract |
PROBLEM TO BE SOLVED: To express not only in vitro expression of a plurality of proteins or a multigene protein complex, for example, an antibody or a protein complex, but also in vitro expression of two or more proteins having a synergistic effect in a specific disease. Provided is an expression system capable of in-vivo or in-situ expression and delivery or in-vivo or in-situ expression and delivery of an antibody or a functional (multigenic) fragment thereof. Gram-positive containing a polycistronic expression unit containing a contiguous sequence of an endogenous gene and one or more exogenous genes transcribeably linked to the 3'end of one or more endogenous genes. It is a bacterium. Consecutive genes endogenous to Gram-positive bacteria and one or more genes exogenous to Gram-positive bacteria transcribeably linked to the 3'end of one or more endogenous genes. A recombinant nucleic acid comprising a polycistron expression unit. [Selection diagram] None |