| abstract |
This embodiment provides a substituted heterocycle derivative compound, a composition comprising the compound, and a compound as described above for epigenetic regulation by inhibiting bromodomain-mediated recognition of the acetyllysine region of proteins such as histones. Relates to the use of the composition. The compositions and methods are useful for treating diseases mediated by abnormal cell signaling, such as inflammatory disorders, cancer, and neoplastic diseases. Certain compounds described herein exhibit selective inhibitory activity against CBP as compared to BRD4. [Selection diagram] None |