http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2019500878-A
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M21-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-241 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0682 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-08 |
| filingDate | 2017-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-01-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-2019500878-A |
| titleOfInvention | Reduction of high molecular weight species, acidic charged species, and fragments in monoclonal antibody compositions |
| abstract | Changing the bioreactor cell culture supply to an extended or continuous supply after the initial period of no supply reduces the levels of high molecular weight, acidic charged and fragment species of monoclonal antibodies expressed in the culture. And enhance the level of afucosylated species of the monoclonal antibody expressed in the culture. Regular fucose injection after an initial period without feed medium injection reduces the level of afucosylated species of monoclonal antibodies expressed in the cell culture. Cell culture procedures can be used to regulate the level of monoclonal antibody species. |
| priorityDate | 2016-01-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 43.