| abstract |
Compositions containing RNA interference (RNAi) compounds complexed or encapsulated in lipid particles are provided. The lipid particles are lipid nanoparticles, liposomes, or combinations thereof. The lipid particles contain cationic lipids, phospholipids, sterols or tocopherols or derivatives thereof, and complex lipids. The present invention also provides a method of treating pulmonary diseases or disorders such as pulmonary fibrosis and sarcoidosis using the composition comprising the RNAi-lipid particles of the present invention. The method includes administering one or more of the RNAi compositions to the lungs of a patient in need thereof, eg, via an inhalation delivery device such as a nebulizer, dry powder inhaler, or metered dose inhaler. . [Selection] Figure 2 |