| abstract |
The present invention provides a technical means (preferably a simple one) for producing a tablet having improved chemical stability of a salt of esomeprazole. SOLUTION: The metal salt of esomeprazole and an additive having low hygroscopicity are contained in an amount of 80.0% by weight or more based on the total weight of the uncoated tablet. An uncoated tablet with reduced moisture absorption, comprising an agent, 1-2 disintegrants, 1-2 binders, and 1-2 lubricants. Additives with low hygroscopicity include lactose hydrate, anhydrous lactose, D-mannitol, xylitol, D-sorbitol, maltitol, maltose, sucrose, powdered reduced maltose water candy and the like. [Selection figure] None |