| abstract |
PROBLEM TO BE SOLVED: To provide a multiparticulate tablet comprising a mixture of a pharmaceutically active substance in the form of at least one enteric coating and a tablet excipient and having an improved gastroprotective action. The present invention also encompasses a method for manufacturing the claimed tablet and its use as a medicament. In the multiparticulate tablet, the excipient mixture comprises xylitol and / or maltitol, each in a compressible form, a disintegrant, a lubricant, and at least one other diluent, a) the proportion of xylitol and / or maltitol is less than 5/95 (mass / mass) relative to other diluents, and the “film integrity test” result is greater than 95%, Preferably more than 97%, and more preferably more than 99%, and the “release test” results are more than 90%, preferably more than 95%. In other embodiments, the tablet is a disintegrating tablet that disintegrates in the oral cavity, with or without chewing. [Selection figure] None |