abstract |
The present invention provides compounds of formula I that can inhibit the activity of SHP2, wherein Y 1 , Y 2 , Y 3 , R 1 , R 2a , R 2b , R 3a , R 3b , R 4b , R 4b , R 5a and R 5b are defined in the Summary of the Invention). The invention further provides methods for preparing the compounds of the invention, pharmaceutical preparations containing such compounds, and methods of using such compounds and compositions in the management of diseases or disorders associated with abnormal activity of SHP2. I will provide a. [Chemical 1] [Selection figure] None |