abstract |
The present invention provides stapled polypeptides of formulas (I) and (VI), (I) (VI) and salts thereof, wherein the group , R 1a , R 1b , R 1c , R 2a , R 3a , R 2b , R 3b , R 4a , R 4b , R A , R Z , L 1a , L 1b , L 2 , L 3 , X AA , v , W, p, m, s, n, t, and q are as defined in this application. The present invention further provides methods for preparing the stapled polypeptides of the present invention from non-staple polypeptide precursors. The present invention further provides pharmaceutical compositions comprising a stapled polypeptide of formula (I) or (VI), and methods of using the stapled peptide. The present invention also provides for the modification of staples after ring closure metathesis. |