| abstract |
An engineered, live, three-dimensional liver tissue composition, the composition comprising one or more layers, each layer comprising one or more hepatocyte types, a live, three-dimensional liver One or more layers agglomerate to form a tissue composition. In some embodiments, the construct is at least one layer comprising a plurality of cell types and at least one layer spatially arranged such that the cell types are in close proximity to each other to create a planar structure Has at least one of a plurality of layers that differ in composition or structure from at least one other layer. Further disclosed is an array of components and a method of manufacturing. Further disclosed is an engineered, live, three-dimensional liver tissue composition used for enhancing or restoring one or more liver functions by in vivo delivery of tissue or utilization of tissue in an extracorporeal device. ing. [Selection] Figure 8 |