abstract |
The present disclosure relates to a class of engineered polypeptides having binding affinity to the neonatal Fc receptor (hereinafter referred to as FcRn), the sequence EX 2 X 3 X 4 AX 6 X 7 EIR WLPNLX 16 X 17 X 18 providing FcRn binding polypeptide comprising a QR X 21 AFIX 25 X 26 LX 28 X 29. The present disclosure also relates to the use of such FcRn binding polypeptides as agents for altering pharmacokinetic and pharmacodynamic properties and as therapeutic agents. |