| abstract |
Antisense oligonucleotides useful for the treatment of hyperproliferation and fibrosis, and the reduction of scarring resulting from wound healing, particularly modified antisense oligonucleotides that effectively inhibit the function of connective tissue growth factor Offer. A modified oligonucleotide consisting of 12 to 30 nucleosides linked, and a sequence portion consisting of at least 12 nucleobases thereof is selected from a specific sequence in a known nucleoside sequence (GenBank accession number NM_001901.2) Compound present in the region to be treated. [Selection figure] None |