abstract |
A mutant recombinant uricase protein which is truncated and has improved structural stability. A genetically modified protein having urate-degrading activity. More specifically, it includes a protein containing a cleaved urate oxidase, a production method thereof, and a PEGylated protein containing a cleaved urate oxidase. A mammalian uriase truncated at 46 amino acids, including a mammalian uricase amino acid sequence truncated at the amino terminus or / and carboxy terminus of the specific sequence, and corresponding to native porcine uricase. [Selection] Figure 1 |