| abstract |
Disclosed are a microsphere containing a slightly soluble drug with improved bioavailability, an oral preparation containing the same, and a production method. A solution containing a water-soluble polymer carrier and a poorly soluble drug, wherein the water-soluble polymer carrier and the poorly soluble drug are dissolved in water and an organic solvent, is spray-dried, and the poorly soluble drug becomes a water-soluble polymer. A poorly soluble drug-containing microsphere dispersed in an amorphous form in a carrier, the microsphere does not contain a surfactant, the water-soluble polymer carrier is hydroxypropyl methylcellulose, and the poorly soluble drug is The amount ratio of the organic solvent and water used is 1: 1 to 3: 1 on a weight basis, and the spray drying is performed at a spray temperature of 80 to 120 ° C. using an atomizer spray dryer and a spray rate. A poorly soluble drug-containing microsphere, an oral preparation containing the same, and a production method, which are performed at 3,000 to 5,000 rpm and an injection rate of 10 to 100 ml / min. The poorly soluble drug is preferably fenofibrate. [Selection figure] None |