| abstract |
Disclosed is a solid dispersion of a drug and a polymer that is hardly soluble in water and a volatile organic solvent. A pharmaceutical composition comprising an ionic drug that is sparingly soluble in water, a cationic species, and a dispersed polymer is disclosed along with a method for forming the composition. The neutral form of the drug has (i) a solubility in aqueous solution of less than 1 mg / mL at pH 6-7, (ii) a solubility in volatile organic solvents of less than 20 mg / mL, and (iii) an acidic pKa value greater than 5. . At least 90% by weight of the drug in the solid dispersion is in an amorphous form. The drug, cationic species, and dispersion polymer make up at least 80% by weight of the solid dispersion. [Selection figure] None |