http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2014523244-A
Outgoing Links
Predicate | Object |
---|---|
classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2510-04 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-85 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
filingDate | 2012-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2014-09-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | JP-2014523244-A |
titleOfInvention | Gene transfer system that reversibly immortalizes mammalian quiescent cells |
abstract | The present invention relates to a transgene that confers externally inducible telomere length homeostasis and cell cycle rotation to human quiescent cells derived from a primary culture, comprising a) at least three promoter sequences, and b) a first promoter. A G1-specific RNA interference sequence operably linked downstream of the sequence, c) a telomere length maintenance gene sequence operably linked downstream of the second promoter sequence, and d) the telomere length maintenance gene sequence in frame A transgene comprising a scaffold / matrix attachment region (S / MAR) element located downstream of and e) a transcriptional regulatory system inducible from the outside. The present invention further provides a method for immortalizing human quiescent cells from primary cultures. [Selection] Figure 1 |
priorityDate | 2011-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 169.