| abstract |
A nitrogen-containing saturated heterocyclic compound useful as a renin inhibitor is provided. A medicament comprising a compound of formula [I] or a pharmacologically acceptable salt thereof. [Wherein, R 1 is a cycloalkyl group or an unsubstituted alkyl group; R 22 is an optionally substituted aryl group, tetrahydronaphthyl group, naphthyridinyl group, pyridyl group, pyrazolopyridyl group, indolyl group, benzofuranyl group , Benzothienyl group, quinolyl group, chromanyl group, dihydrobenzofuranyl group, indazolyl group, etc .; R is a lower alkyl group or is bonded to R 22 at the end to form a ring; T is a carbonyl group Z is —O—, —NH— or a single bond; R 3 , R 4 , R 5 and R 6 are the same or different and each represents a hydrogen atom, an optionally substituted carbamoyl group or an optionally substituted; Good alkyl group. ] [Selection figure] None |