| abstract |
Methods of treating aging or conditions associated with aging, symptoms or diseases; methods of promoting hair growth, regrowth or pigmentation (or prevention of hair loss); methods of increasing adenosine receptor expression in dermal cells (hair Skin condition or disease or at least one symptom thereof (eg, wrinkles, hyperpigmentation, redness, rosacea, dryness, cracks, loss of tension, loss of elasticity, including cosmetic treatment); A method of treating thinning and loss of vitality). The method includes administering a sufficient amount of a disclosed CBP / catenin (eg, CBP / β-catenin) antagonist, particularly where administration is compared to symmetrical division in an appropriate somatic stem cell population. In an amount and manner sufficient to increase the number of asymmetric replication divisions, or at the expense of symmetric division in an appropriate somatic stem cell population. [Selection] Figure 15 |