| abstract |
The present invention includes fluorescent diagnosis of non-neoplastic indications such as cancer, infections and other hyperproliferative diseases PDT, arthritis, inflammatory diseases, viral or bacterial infections, skin diseases, ophthalmic diseases or urological diseases, and Methods are provided for obtaining biologically active compounds that can be used as photosensitizers in diagnostic and therapeutic applications for the treatment of PDT. One embodiment of the invention consists of a method for synthesizing diketo-chlorins as precursors. In yet another embodiment, these precursors are converted to β-functionalized hydroxy- and dihydroxy-chlorins. Another embodiment is for providing amphiphilic compounds with higher membrane affinity and increased PDT efficiency. Another embodiment consists of the formulation of the desired isomer into a liposomal formulation that is injected while avoiding undesirable effects such as precipitation at the injection site of tetrapyrrole-based or delayed pharmacokinetics. [Selection] Figure 1 |