| abstract |
Pyrazol-4-yl-heterocyclyl-carboxamide compounds of formula I, including stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof, wherein X is thiazolyl, picolinyl, pyridinyl , Pyrimidinyl, or fluoro-pyridinyl rings are useful for the inhibition of Pim kinase and for treating diseases such as cancer mediated by Pim kinase. Disclosed are methods of using compounds of formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such diseases or related pathological conditions in mammalian cells. |