| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-122
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-342
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-533
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-321
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-322
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-344
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-141 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-713
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1138
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-111
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1131
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1135 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-713 |
| filingDate |
2009-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2012-06-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2012512651-A |
| titleOfInvention |
Extended DICER substrate drugs and methods for specific inhibition of gene expression |
| abstract |
The present invention relates to reducing target gene expression in a cell comprising contacting the cell with an amount of an isolated double stranded nucleic acid (dsNA) effective to reduce target gene expression in the cell. Compositions and methods are provided. The dsNAs of the present invention are deoxyribonucleotide patterns designed to direct the site of Dicer enzyme cleavage within the dsNA molecule (in most embodiments, the pattern comprises at least one deoxyribonucleotide-deoxyribonucleotide base pair). Have The deoxyribonucleotides of the dsNA molecules of the invention can be excised via Dicer cleavage to produce active siRNA agents that no longer contain a deoxyribonucleotide pattern (eg, deoxyribonucleotide-deoxyribonucleotide base pairs). Located in the area. Such DNA-expanded Dicer-substrate siRNAs (DsiRNAs) have proven to be more effective RNA inhibitory agents than the corresponding double-stranded RNA-extended DsiRNAs. DsiRNA agents have also been found to tolerate guide strand mismatches. [Selection] Figure 1 |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2016520312-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017068791-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10435692-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2021500026-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10487330-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2021191278-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2017502668-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10465195-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-7109416-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2019107029-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11060093-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2020036603-A |
| priorityDate |
2008-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |