abstract |
The present invention provides a compound of formula (Ia): a pharmaceutically acceptable salt of this compound, in which R1, R2, R3, R4, R5, X, Y and n are defined herein. Defined in the certificate. Also, methods for producing these compounds as set forth herein; in use in inhibiting acid ceramidase and ceramidase-related activity, and in the treatment and / or prevention of diseases involving undesirable ceramidase or sphingosine kinase activity, Disclosed for use as a drug or prodrug (precursor), including but not limited to cancer, cancer metastasis, atherosclerosis, stenosis, inflammation, asthma and atopic dermatitis Not. [Selection figure] None |