| abstract |
[Object] To provide an aryl sulfamate derivative or a pharmacologically acceptable salt thereof, which has a steroid sulfatase inhibitory activity and is useful for treating or preventing a steroid hormone-dependent disease. The formula (I) Embedded image [Wherein, R 1 and R 2 are the same or different and each represent a hydrogen atom or lower alkyl, Y 1 is (In the formula, one of Q 1 , Q 2 , Q 3 , Q 4 and Q 5 represents a carbon atom bonded to OSO 2 NR 1 R 2, and the other Q 1 , Q 2 , Q 3 , Q 5 4 and Q 5 are the same or different and each represents a nitrogen atom or the like), Y 2 represents a substituted or unsubstituted lower alkylene or the like, and R 3 represents a substituted or unsubstituted cycloalkyl or the like And a pharmacologically acceptable salt thereof. [Selection diagram] None |