| abstract |
Disclosed is a preparation capable of concealing discomfort in the oral cavity, such as bitterness and numbness, when the preparation is taken in the oral cavity and capable of quickly releasing an active ingredient in the stomach. Provided are microparticles for preparation and formulations containing the same. In one aspect, the fine particles for formulation include a core particle containing an acid addition salt of a basic drug and a pharmaceutically acceptable inorganic or organic basic compound, and an outer side of the core particle. It consists of a formed water-permeable film containing a water-insoluble polymer. When taken, the diffusion and dissolution of basic drugs is suppressed in the oral cavity, but the film breaks in the stomach or upper small intestine, and the drug is quickly released. Is released. In another aspect, the microparticle for formulation comprises a core particle containing an acid addition salt of a basic drug, and a pharmaceutically acceptable inorganic or organic basic compound formed outside the core particle. An intermediate film containing a water-soluble polymer, and a water-permeable outermost film containing a water-insoluble polymer formed on the outer side of the intermediate film. Diffusion elution of a sex drug is suppressed, but the outermost layer film is broken in the stomach or upper part of the small intestine, and the drug is rapidly released. [Selection figure] None |