| abstract |
An isolated neutralizing anti-ALK-1 monoclonal antibody that binds to primate ALK-1, preferably binds to the ECD of primate ALK-1. A human that binds to the extracellular domain (ECD) of activin receptor-like kinase-1 (ALK-1) and functions to abolish the ALK-1 / TGF-β-1 / Smad1 signaling pathway An antibody comprising an antibody and an antigen-binding portion thereof. Heavy and light chain immunoglobulins derived from human anti-ALK-1 antibodies, and nucleic acid molecules encoding such immunoglobulins. Methods for making human anti-ALK-1 antibodies, compositions comprising these antibodies, and methods using the antibodies and compositions. And a transgenic animal or plant comprising the nucleic acid molecule. [Selection] Figure 1 |