| abstract |
The present invention provides small molecules that function as antagonists of the interaction between p53 tumor suppressor and protein MDM2, and therapeutic agents for the treatment of cancer and other diseases. A compound having the following general formula I, or a pharmaceutically acceptable salt or prodrug thereof: [In the formula I, X is CH, O, N, or S, and Y is O, S, or NR ′. ] [Selection figure] None |