| abstract |
The present invention provides a polypeptide having a complex amino acid sequence derived from a consensus sequence corresponding to capsid proteins of two or more circulating strains of non-enveloped virus. In particular, the present invention provides virus-like particles comprising at least one complex polypeptide. Such virus-like particles have antigenic epitopes of two or more circulating strains of non-enveloped virus and increase antiserum cross-reactivity to one or more circulating strains of the non-enveloped virus. Also disclosed are methods for producing composite virus-like particles and vaccine formulations comprising composite virus-like particles. |