| abstract |
Compounds of formula (I) and pharmacologically acceptable salts and prodrugs thereof: [Chemical 1] Wherein Ar 1 and Ar 2 are aryl or heteroaryl, a is 0-5, R 1 is alkyl, halogen, haloalkyl, alkoxy, haloalkoxy, alkoxycarbonyl, carboxyl, hydroxyl, amino, Monoalkylamino, dialkylamino, nitro, acylamino, alkoxycarbonylamino, alkylsulfonyl, alkylsulfonylamino or cyano, wherein a is greater than 1 and each substituent R 1 is the same or different. may, b is 0 to 5, R 2 is alkyl, halogen, haloalkyl, haloalkoxy, alkoxy, alkoxycarbonyl, carboxyl, hydroxyl, amino, monoalkylamino, dialkylamino, nitro, acylamino, alkoxycarbonyl Arylamino, alkylsulfonyl, and alkylsulfonylamino, or cyano, wherein, b is greater than 1, each substituent R 2 may be independently identical or different, V is, (CR 3a R 3b) p CON (R 3b ) X and (CR 3a R 3b ) p N (R 3b ) CO (X), wherein the group is in the 3 (meth) position or 4 with respect to the substituent Z In the (para) position, W is selected from the group consisting of NR 4a , O, S, S═O, SO 2 and C (R 4a R 4b ) 2 , X is hydrogen, alkyl, hydroxyalkyl, alkoxy Alkyl, haloalkoxyalkyl, aryloxyalkyl, cycloalkyl, aryl, heteroaryl, polyalkylene glycol, aminoalkyl, monoalkylaminoalkyl Dialkylaminoalkyl, alkyl, carboxyalkyl substituted with a group of formula NR8R9, wherein R8 and R9 together with the nitrogen atom to which they are attached form a saturated or partially unsaturated heterocyclic group , Alkoxycarbonylalkyl, haloalkoxycarbonylalkyl or aralkyloxycarbonylalkyl, Y and Z are the same or different and each represents (CR 5a R 5b ) n1 , C═O, SO 2 , C (═O) NR 5a , C (═O) NR 5a SO 2 and C═ O (R 5a R 5b ) is a substituent selected from the group consisting of n 2 and R 3a , R 3b , R 4a , R 4b , R 5a and R 5b are the same or different and each is a hydrogen , Alkyl, cycloalkyl, aryl and heteroaryl, wherein n1 and n2 are the same or different and each is 0-2 and p is 0-2) is a potassium ion channel modulator And is particularly useful for the treatment and prevention of diseases such as pain and lower urinary tract disease. [Selection figure] None |