abstract |
The present invention relates to the variable domain (VHH) of a camelid heavy chain antibody directed to an intracellular target, with an isoelectric point of at least 8.5, for targeting the intracellular target or for producing a peptide vector. Domain) use. In particular, the present invention relates to a VHH domain directed to glial fibrillary acidic protein and its use to produce a therapeutic or diagnostic agent. |