| abstract |
The present invention relates to the diagnosis and treatment of neurodegenerative diseases, ischemic events and central nervous system injury, and to damaged neuronal tissue whether or not due to tissue trauma or chronic or acute degenerative changes. Compositions and methods are provided for amelioration or alleviation of associated symptoms and signs. The present invention specifically relates to the discovery that annexin II expression is involved in apoptosis caused by oxidative stress and the discovery that antisense annexin II RNA and annexin II siRNA protected cells from this apoptosis. . |