| abstract |
X and Y are each N or C; at least one of X and Y is N; Z is a single bond or an optionally substituted linking group; and R1 is hydrogen or R2 is amino or a substituent; N * is amino when RI is hydrogen, or ═NH when R1 is a substituent; or N * is Ra And Rb is independently the group NRaRb, which is H or an alkyl group; or N * is an optionally substituted piperazinyl ring; and A is a triazo via R2 / A compound of general structure which may be linked to a diazo ring to form a condensed polycyclic ring, optionally substituted heterocyclic or carbocyclic ring system is sodium Channel blocker Disorders in mammals that are sensitive to antifolates, especially sputum, multiple sclerosis, glaucoma and webitis, brain trauma and brain ischemia, stroke, head injury, spinal cord injury, surgical trauma, nerves Degenerative disease, motor neuron disease, Alzheimer's disease, Parkinson's disease, chronic inflammatory pain, neuropathic pain, migraine, bipolar disorder, mood, anxiety, and cognitive impairment, schizophrenia, and trigeminal autonomic nerve headache It is shown to be suitable for the treatment of disorders of the body; the treatment of cancer in mammals; [Chemical 1] [Selection figure] None |