abstract |
A trisubstituted pyrimidine compound having an excellent PDE10 inhibitory action is provided. The general formula [I 0 ] [Wherein, one of X 1 and X 2 is N and the other is CH; A is * —CH═CH—, * —C (Alk) ═CH—, * —CH 2. —CH 2 — or * —O—CH 2 — ( * is a bond to R 1 ); Alk is a lower alkyl group; Ring B is an optionally substituted nitrogen-containing aliphatic group R 1 is an optionally substituted quinoxalinyl or an optionally substituted quinolyl; Y 0 is a mono- or di-substituted amino] or a trisubstituted pyrimidine compound A pharmaceutical composition comprising a pharmacologically acceptable salt as an active ingredient. [Selection figure] None |