| abstract |
B cell precursors (pre-B cells) produce μ heavy chains, but express a set of B lineage specific genes called VpreB (l-3) and λ5, respectively, instead of fully developed light chains It has been identified in the bone marrow as lymphocytes. The present invention relates to constructs and libraries comprising antibody surrogate light chain sequences. In particular, the invention relates to a construct comprising a VpreB sequence optionally partnered with another polypeptide, such as, for example, an antibody heavy chain variable domain sequence, and a library containing it. |