| abstract |
In one or more embodiments of the present invention, a method of synthesizing a complex of a pharmaceutically active compound is provided, the method comprising, at one or more synthetically available positions within an intermediate compound, Attaching at least one water soluble oligomer directly or through a linker group and completing the synthetic pathway to yield a complex of pharmaceutically active compounds. The present invention provides a method for preparing small molecule drugs that are chemically modified by covalent bonding of water-soluble oligomers resulting from water-soluble oligomer compositions. Such drugs are produced by modifying the synthetic pathway to attach the oligomer to the intermediate compound and then completing the synthetic pathway. |