| abstract |
The present invention provides a reductase suitable for industrial production of optically active compounds. [MEANS FOR SOLVING PROBLEMS] A modified reductase comprising an amino acid sequence characterized by having at least eight amino acid substitutions from a) to h) below in the amino acid sequence of a wild-type reductase derived from Rhodococcus erythropolis: a) third B) the 4th amino acid is replaced by leucine, c) the 12th amino acid is replaced by glycine, d) the 42nd amino acid is replaced by leucine, and e) the 67th amino acid is replaced by arginine. F) 125th amino acid is replaced with methionine, g) 180th amino acid is replaced with isoleucine, and h) 327th amino acid is replaced with valine. [Selection figure] None |