| abstract |
Provided is a solid pharmaceutical composition that is useful as a prophylactic / therapeutic agent for metabolic diseases and has excellent pharmaceutical properties. (A) a nucleus containing candesartan cilexetil, a low melting point oily substance and a sugar alcohol; (b) a first layer containing a high molecular weight polymer and covering the nucleus; c) A solid pharmaceutical composition comprising pioglitazone hydrochloride and a second layer covering the first layer. Preferably, the low melting point oily substance is an alkylene oxide polymer having a molecular weight of 1000 to 10000, the sugar alcohol is mannitol, and the high molecular weight polymer is hydroxypropylmethylcellulose, hydroxypropylcellulose, polyvinylpyrrolidone or polyvinylalcohol, or a polymer thereof. The composition, which is a mixture of two or more coalesces. [Selection figure] None |