| abstract |
Selective PDE4 inhibition is achieved with novel compounds such as 4- (substituted phenyl) -2-pyrrolidinone compounds. The compounds of the present invention have the formula (I) wherein R 1 , R 2 and R 3 are defined herein. 〕belongs to. The disclosure also describes methods for making such compounds, compositions containing such compounds, and cognitive impairment, memory impairment, mental illness, schizophrenia, depression, allergic or inflammatory diseases, chronic obstructive lung It relates to use for the treatment of diseases, neurodegeneration, stroke, Alzheimer's disease, multiple sclerosis. [Chemical 1] |