| abstract |
In the present invention, carbon at position 20 is substituted with cycloalkyl (for example, cyclopropyl), carbon at position 16 is a double bond, and carbon at position 23 is a single bond, a double bond, or a triple bond. provides a vitamin D 3 analogue of cholecalciferol. The carbon at position 25 is substituted with various alkyl and haloalkyl. The present invention provides pharmaceutically acceptable esters, salts and prodrugs thereof. Further disclosed are methods for using the compounds for the treatment of vitamin D 3 related conditions and pharmaceutical compositions comprising the compounds. |