| Predicate |
Object |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1709 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7088
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 |
| filingDate |
2005-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2008-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2008511297-A |
| titleOfInvention |
ICA512 is involved in insulin secretion and gene expression in β-cells |
| abstract |
The present invention relates to the presence or activity of ICA512 or a derivative or fragment thereof, which can be cleaved by μ-calpain to yield a C-terminal fragment of ICA512 that has the ability to target to the nucleus. The present invention relates to a method for stimulating the expression of peptide hormones in peptide hormone secreting endocrine cells or neurons comprising the step of promoting in the cells or neurons. Preferably, the endocrine cell is a β-cell and the peptide hormone is insulin. [Selection figure] None |
| priorityDate |
2004-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |