| abstract |
The present invention relates to methods and compositions for use in mediating immunosuppressive responses. The composition of the present invention comprises an exosome having immunosuppressive activity. Such exosomes may be derived from a variety of different cell types including antigen presenting cells such as dendritic cells and macrophages. Prior to isolation of the exosome, the cell is genetically engineered to express a molecule capable of enhancing the immunosuppressive activity of the exosome and / or the cell is subjected to one or more actions such as cytokines or cytokine inhibitors It can be exposed to a substance, which can also enhance the immunosuppressive activity of the exosome. The present invention also relates to the use of such exosomes for the treatment of diseases and disorders associated with unwanted activation of the immune system. The invention also encompasses exosomes isolated directly from serum that has been shown to be immunosuppressive. |