| abstract |
Disclosed is a novel compound having a non-peptidic small molecule caspase inhibitory action that is not peptidic, is strong, stable, and penetrates the membrane to produce effective apoptosis inhibition in vivo. A compound of the following formula, or a pharmaceutically acceptable salt thereof: Wherein X 1 and X 3 are independently selected from nitrogen or carbon, X 2 is selected from valence bond, oxygen, sulfur, nitrogen or carbon, R 1 is hydrogen atom or substituted aliphatic group, etc. In particular, a fluoromethyl group is preferred, R2 represents a carboxyl group, R3 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms, etc.) [Selection figure] None |