| abstract |
PROBLEM TO BE SOLVED: To provide a prodrug of a caspase inhibitor having the ability to cross the blood brain barrier and penetrating the brain and central nervous system at a therapeutically useful level. A compound having the structure shown in Formula I, wherein X is —OR 1 or —N (R 5 ) 2 , Y is halo, trifluorophenoxy or tetrafluorophenoxy, and A compound wherein R 1 , R 2 , R 3 , R 4 and each R 5 are each as defined in the specification. [Selection figure] None |