| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-05
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0312
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4711
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0275 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K-
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 |
| filingDate |
2005-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2007-11-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-2007530035-A |
| titleOfInvention |
Transgenic model for Alzheimer's disease |
| abstract |
The present invention relates to a DNA sequence encoding a heterologous amyloid precursor protein (APP) comprising at least an Arctic mutation (E693G) and a further AD (Alzheimer's disease) pathogenic mutation, or an intracellular solubility comprising an A peptide. It relates to a transgenic non-human animal that expresses at least one transgene, including additional transgenes that result in an increased amount of A aggregation and affect the onset of AD. The present invention also relates to a method for producing the transgenic animal and a method for screening a therapeutic or diagnostic agent useful for the treatment or diagnosis of Alzheimer's disease. [Selection] Figure 1 |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021172925-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101634244-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20150145865-A |
| priorityDate |
2004-03-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |