abstract |
The present invention relates to the prevention and treatment of Alzheimer's disease (AD). More specifically, the present invention relates to the use of non-wild type protofibrils or compound (s) having protofibril forming activity in active immunization for the purpose of treating or preventing AD. The invention further relates to aβ-Arc, a peptide with high protofibril forming activity, and some applications thereof, such as antibodies against the peptide for passive immunization against AD. |