| abstract |
Disclosed are devices and methods for reducing, eliminating, preventing, suppressing or treating hemostatic devices, such as biological sealants, or tissue responses to vascular procedures. The present invention uses a combination of absorbable and biocompatible matrix materials and various therapeutic agents such as anti-proliferative agents or antibiotics, by applying the combination to a vascular puncture or incision, or Hemostasis is achieved after interventional vascular catheter insertion to treat neointimal hyperplasia and stenosis. A matrix of material, such as collagen, stores therapeutic agents such as rapamycin (sirolimus) and its derivatives and analogs for delivery to tissue sites at risk of vascular proliferation, infection, inflammation, fibrosis or other tissue reactions Become a body. |