| abstract |
The present disclosure provides various small molecule, guanidine-containing molecules that can act as MC4-R agonists. This compound is useful in treating MC4-R mediated diseases when administered to a subject. This compound has the formula IA and formula IB. IA and IB have the formula where Z is shown below and the remainder of the variable portion has the following structure as defined herein. The present invention provides potent and specific agonists that are small molecules. For example, according to one aspect of the present invention, there is provided Formula IA, IB, mixtures thereof, or pharmaceutically acceptable salts thereof. |