| abstract |
Various molecules containing a small molecule guanidine structure that can function as MC4-R agonists are provided. These compounds are useful for the treatment of diseases related to MC4-R when administered to patients. The compounds have the structures IA, IB, IC, the meaning of which is defined herein. The present invention provides compounds wherein the t1 / 2 value of the compound in tissues with high blood perfusion, such as brain, liver, kidney and heart, is less than 35, 30, 25, 20, 15, 10 or 5 hours. In some such examples, the t1 / 2 value of the patient receiving the compound is about 4 hours or less. |