| abstract |
Provided is a method for producing α-glycerophosphorylcholine crystals, characterized in that a hydrolytic ring-opening reaction of a 1,3-dioxolane-glycerylphosphorylcholine compound represented by a specific formula is carried out in the presence of a cationic ion exchange resin. To do. A 1,3-dioxolane compound represented by a specific formula is reacted with 2-chloro-2-oxa-1,3,2-dioxaphosphorane represented by a specific formula and trimethylamine. To obtain a 1,3-dioxolane-glycerylphosphorylcholine compound represented by a specific formula, which is subjected to a hydrolytic ring-opening reaction in a water-containing solvent in the presence of a cationic ion exchange resin, and then coexistent with water. A method for producing an α-glycerophosphorylcholine crystal, which is crystallized by drying under reduced pressure in the presence of a boiling solvent. [Selection figure] None |